Clinical assessment of human lymph flow using removal rate constants of interstitial macromolecules: a critical review of lymphoscintigraphy.
Identifieur interne : 007317 ( Main/Exploration ); précédent : 007316; suivant : 007318Clinical assessment of human lymph flow using removal rate constants of interstitial macromolecules: a critical review of lymphoscintigraphy.
Auteurs : S. Modi [Royaume-Uni] ; A W B. Stanton ; Peter Mortimer (dermatologue) [Royaume-Uni] ; J R LevickSource :
- Lymphatic research and biology [ 1539-6851 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- imagerie diagnostique : Lymphoedème.
- physiologie : Lymphe.
- Humains, Lymphoscintigraphie.
English descriptors
- KwdEn :
- MESH :
- diagnostic imaging : Lymphedema.
- physiology : Lymph.
- Humans, Lymphoscintigraphy.
Abstract
Edema is a common clinical problem, and the daily avoidance of edema depends critically on the lymphatic system, which clears leaked plasma proteins and fluid from the interstitial compartment. There is often confusion as to the difference between chronic edema and lymphedema. Lymphedema is by definition primarily a disease of impaired lymphatic drainage and lymph flow, and progress in lymphedema research, currently an increasingly active field, requires a clinically viable method for the quantitative assessment of lymph drainage rate in patients. Measurement of the rate of clearance of a new protein marker, radiolabelled human immunoglobulin, from skin, subcutis, and muscle provides a way of measuring human lymph flow quantitatively and is the only viable clinical method currently available. Considerable strides have been made over the last 5-10 years in evaluating the method and its pitfalls, including potential complications such as vascular clearance, peripheral lymphovenous communications and label dissociation. The review assesses critically, for the first time, the evidence relating to the method: its pitfalls; human lymph flow in various healthy and oedematous tissues; and how this is altered in hyperfiltration edemas, inflammation, vasoconstriction and various primary and secondary human lymphedemas.
DOI: 10.1089/lrb.2007.5306
PubMed: 18035937
Affiliations:
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Modi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Cardiac & Vascular Sciences (Dermatology), St. George's Hospital Medical School, University of London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiac & Vascular Sciences (Dermatology), St. George's Hospital Medical School, University of London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:18035937</idno><idno type="pmid">18035937</idno><idno type="doi">10.1089/lrb.2007.5306</idno><idno type="wicri:Area/PubMed/Corpus">003466</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003466</idno><idno type="wicri:Area/PubMed/Curation">003466</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003466</idno><idno type="wicri:Area/PubMed/Checkpoint">003466</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003466</idno><idno type="wicri:Area/Ncbi/Merge">002A27</idno><idno type="wicri:Area/Ncbi/Curation">002A27</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A27</idno><idno type="wicri:doubleKey">1539-6851:2007:Modi S:clinical:assessment:of</idno><idno type="wicri:Area/Main/Merge">007463</idno><idno type="wicri:Area/Main/Curation">007317</idno><idno type="wicri:Area/Main/Exploration">007317</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical assessment of human lymph flow using removal rate constants of interstitial macromolecules: a critical review of lymphoscintigraphy.</title><author><name sortKey="Modi, S" sort="Modi, S" uniqKey="Modi S" first="S" last="Modi">S. Modi</name><affiliation wicri:level="4"><nlm:affiliation>Division of Cardiac & Vascular Sciences (Dermatology), St. George's Hospital Medical School, University of London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiac & Vascular Sciences (Dermatology), St. George's Hospital Medical School, University of London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="ISSN">1539-6851</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Lymph (physiology)</term><term>Lymphedema (diagnostic imaging)</term><term>Lymphoscintigraphy</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Lymphe (physiologie)</term><term>Lymphoedème (imagerie diagnostique)</term><term>Lymphoscintigraphie</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphe</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Lymphoscintigraphy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Lymphoscintigraphie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Edema is a common clinical problem, and the daily avoidance of edema depends critically on the lymphatic system, which clears leaked plasma proteins and fluid from the interstitial compartment. There is often confusion as to the difference between chronic edema and lymphedema. Lymphedema is by definition primarily a disease of impaired lymphatic drainage and lymph flow, and progress in lymphedema research, currently an increasingly active field, requires a clinically viable method for the quantitative assessment of lymph drainage rate in patients. Measurement of the rate of clearance of a new protein marker, radiolabelled human immunoglobulin, from skin, subcutis, and muscle provides a way of measuring human lymph flow quantitatively and is the only viable clinical method currently available. Considerable strides have been made over the last 5-10 years in evaluating the method and its pitfalls, including potential complications such as vascular clearance, peripheral lymphovenous communications and label dissociation. The review assesses critically, for the first time, the evidence relating to the method: its pitfalls; human lymph flow in various healthy and oedematous tissues; and how this is altered in hyperfiltration edemas, inflammation, vasoconstriction and various primary and secondary human lymphedemas.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><noCountry><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Modi, S" sort="Modi, S" uniqKey="Modi S" first="S" last="Modi">S. Modi</name></region><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">Peter Mortimer (dermatologue)</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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